A Cyclones weather alert is issued before each home game warning opposing fans that Iowa State is taking the field.
This Saturday, fans are urged to be prepared for the real thing as showers and storms are expected to roll into the Ames area.
"We plan for the worst and hope for the best," said Rob Bowers, the Deputy Police Chief for the Iowa State University Police Department.
It's nothing new for Bowers.
He led the safety efforts in 2005, when a tornado touched down just miles from Jack Trice Stadium before a game.
He's preparing for the same success this Saturday.
"If somebody's on the edge, we would hope they would look at all the planning that's been done and feel really good about going to the game now,” said Bowers.
Here are some safety tips for the big game.
Pay attention to messages on the PA system and voice activated sirens.
Since 2005, they've been installed at every gate and will tell you how to stay safe.
Second, make sure your group knows where to evacuate.
If needed, Hilton Coliseum and the vet med building could be opened.
Finally, take action.
Safety can be as simple as downloading a weather app or following Iowa State football on Twitter for the latest updates.
"We'll give people the earliest and best notice we can but I emphasize that early preliminary planning."
It's advice that will be valuable for Iowa State students like Stu Millar and Alex Ernst.
The Cyclones seniors have no plans to miss the big game.
"This is Cyclones country. If a cyclone is coming, you better watch out. That's just our mascot showing up to the game," said Millar.
"I'll be in the stands for the game. I wouldn't miss it for the world. Especially not against a top 10 team," Ernst told Channel 13 News.