Five Story County fire departments battled flames and the heat Monday night.
The Kelly Fire Department was called to a house fire south of Ames around 5 p.m.
Four other departments were called in in order to allow firefighters to rotate off the front line in the sweltering heat.
Two people inside the home made it out safely.
The home is a total loss.
Firefighters also had to battle grass fires in the ditch in front of the home.